CAREERS

Purpose:

The purpose of the Research and Development Scientist is to actively participate in the generation and characterisation of antibodies within the Adaptate Biotherapeutics antibody therapeutics portfolio. The focus of the work will be on the development and running of biological assays to functionally characterise biologics in in-vitro and ex-vivo systems. The role is primarily laboratory-based and you’ll work within a dynamic cross-functional Adaptate R&D team.

Key Accountabilities:

• Design, perform, analyse and interpret experiments to deliver agreed work packages to agreed timelines and objectives.
• Drive assay development and implement new methods for a diverse range of immunology-focused and translational assays.
• Provide scientific knowledge and expertise in antibody evaluation, gamma delta T cell biology and molecular biology.
• Identify, optimise, and solve problems associated with own experiments as part of a team.
• Support scientific research of R&D team via use of electronic lab notebook, producing summary presentations and reports, update team as necessary on work / project status and milestone delivery.
• Operate and validate all items of equipment or IT needed for experimentation, data analysis, storage and data entry.
• Proactively support delivery from the whole R&D team and actively contribute to the smooth running of the laboratory.

Education/Experience:

• Educated to PhD degree level or first degree with 4+ years’ experience in a relevant scientific discipline.
• Experience working in a laboratory in an industrial or small company start up is preferred.
• Extensive experience of mammalian cell culture is essential, with primary cells and complex cell culture models (e.g. 3D) a plus.
• Experience in antibody drug discovery and assay development.
• Good understanding of immunology/T cell biology and previous experience in immuno-oncology is preferred.
• Understanding of the process of therapeutic antibody generation and the development of antibodies as therapeutic drugs.
• Previous experience performing cell-based assay techniques such as imaging-based assays and flow cytometry.

Skills/Competencies:

• Commitment to high-quality research standards, with attention to detail and data integrity.
• Strong ability to implement creative and practical solutions to problems to advance technically challenging projects.
• Ability to work independently, take the initiative and exercise good scientific judgment.
• Flexible and pragmatic, with an ability to prioritise a varied workload to ensure that studies meet challenging timelines.
• Ability to effectively interact and collaborate with colleagues at all levels with excellent communication, interpersonal and presentation skills.
• Commitment to continual improvement by reading and applying the latest scientific literature, methodologies and technology where appropriate.
• Enjoys working in a fast moving, dynamic start-up environment and able to work flexible hours (when required).
• Experience of working to high health and safety standards and willing to comply with Adaptate Standard Operating Procedures and Policies.
• Good IT skills including confidence with use of scientific software.

Purpose:
A laboratory-based role supporting the characterisation of antibodies within the Adaptate Biotherapeutics portfolio to deliver pre-clinical work packages within antibody therapeutics portfolio. The work will include the development and running of biological assays to characterise the antibodies, the preparation and maintenance of primary and cell line cultures and contribution to the smooth running of the laboratory. The role is primarily laboratory-based and you’ll work within a dynamic cross-functional Adaptate R&D team.

Key Accountabilities:

• Drive assay development and implement new methods for a range of immunology-focused and translational assays.
• Conduct of phenotypic and functional analysis of cells according to experimental plans agreed with supervisor. This will include flow cytometry, imaging and cytokine analysis.
• Primary cell culture of lymphocytes, including γδ T cells, from human tissue (skin, blood, tumour tissue).
• Maintenance and management of primary cell cultures and tumour cell lines.
• Accurate and timely data analysis and reporting, including use of electronic lab notebook and summarising of data in presentations.
• Participates in the smooth running of the laboratory, including ordering consumables and preparation of shared materials

Education/Experience:

• Educated to first degree level or MSc in a relevant scientific discipline.
• 1-2 yrs+ experience working in a laboratory in an academic or industrial setting.
• Experience with media preparation and cell culture, including primary cells preferred.
• Experience of cell-based techniques such as flow cytometry or live cell imaging preferred.
• Good understanding of immunology/T cell biology and previous experience in immuno-oncology is a plus.

Skills/Competencies:

• Enthusiastic and highly motivated to learn new skills.
• Ability to work independently, take the initiative and exercise good scientific judgment.
• Proven ability to work as part of a team and engage constructively with colleagues.
• Good IT skills and a readiness to learn the relevant scientific software.
• Flexible and pragmatic, with an ability to prioritise a varied workload to ensure that studies meet challenging timelines.
• Commitment to high-quality research standards, with attention to detail and data integrity.
• Experience of working to high health and safety standards and willing to comply with Adaptate Standard Operating Procedures and Policies.
• Enjoys working in a fast moving, dynamic start-up environment and able to work flexible hours (to fit with tissue availability when required).